Triglycerides are synthesized by means of esterification of fatty acids to glycerol. Fatty acid esterification takes vicinity in the endoplasmic reticulum of cells through metabolic pathways wherein acyl organizations in fatty acyl-CoAs are transferred to the hydroxyl companies of glycerol-3-phosphate and diacylglycerol. 3 fatty acid chains are bonded to each glycerol molecule. Each of the 3 -OH agencies of the glycerol reacts with the carboxyl end of a fatty acid chain (-COOH). Water is eliminated and the closing carbon atoms are linked by using an -O- bond through dehydration synthesis.
Both the adipose tissue and the liver can synthesize triglycerides. Those produced by the liver are secreted from it inside the form of very-low-density lipoproteins (VLDL). VLDL debris are secreted without delay into blood, in which they function to supply the endogenously derived lipids to peripheral tissues.