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- Bilirubin > 15 mg/dl (255 μmol/l), now not responding to traditional medical care alter three days
- Renal dysfunction or hepatorenal syndrome.
- Hepatic encephalopathy ≥ II
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- 3 to 5 eight-hour remedy periods on consecutive days
- Continuous treatment with hemodynamic instability (anyhow, remedy kit must get replaced every 24 hours)