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• Bilirubin > 15 mg/dl (255 μmol/l), now not responding to traditional medical care alter three days

• Renal dysfunction or hepatorenal syndrome.

• Hepatic encephalopathy ≥ II

Treatment Schedule:

• 3 to 5 eight-hour remedy periods on consecutive days

• Continuous treatment with hemodynamic instability (anyhow, remedy kit must get replaced every 24 hours)