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The glyoxylate cycle makes use of five of the eight enzymes associated with the tricarboxylic acid cycle: citrate synthase, aconitase, succinate dehydrogenase, fumarase, and malate dehydrogenase. The cycles range in that in the glyoxylate cycle, isocitrate is converted into glyoxylate and succinate by way of isocitrate lyase (ICL) instead of into α-ketoglutarate. This bypasses the decarboxylation steps that take place within the citric acid cycle (TCA cycle), allowing easy carbon compounds to be used within the later synthesis of macromolecules, which include glucose. Glyoxylate is subsequently combined with acetyl-CoA to provide malate, catalyzed by malate synthase. Malate is likewise shaped in parallel from succinate with the aid of the action of succinate dehydrogenase and fumarase.