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• The opposite Krebs cycle (additionally called the reverse tricarboxylic acid cycle, the opposite TCA cycle, or the reverse citric acid cycle, or the reductive tricarboxylic acid cycle, or the reductive TCA cycle) is a sequence of chemical reactions which can be used by some micro organism to provide carbon compounds from carbon dioxide and water through the use of strength-rich lowering dealers as electron donors.

• The response is the citric acid cycle run in reverse: in which the Krebs cycle takes carbohydrates and oxidizes them to CO2 and water, the reverse cycle takes CO2 and water to make carbon compounds. This technique is utilized by some micro organism (including Aquificota) to synthesise carbon compounds, every now and then the usage of hydrogen, sulfide, or thiosulfate as electron donors. In this method, it may be seen as an alternative to the fixation of inorganic carbon in the reductive pentose phosphate cycle which takes place in a extensive style of microbes and better organisms.