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Another possible clinical utility of human artificial ovaries is re-transplanting ovarian follicles which have been grown in vitro. In animal models, pre-antral ovarian follicles have been grown in vitro, then isolated and implanted into a biodegradable 3-D synthetic ovary for re-transplantation again into the animal ovary. This method has proven capability achievement in animal models, however in humans stays a theoretical concept for now.