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A proposed approach to avoid cellular rejection is to set off donor non-responsiveness the use of hematopoietic chimerism. Donor stem cells are introduced into the bone marrow of the recipient, where they coexist with the recipient’s stem cells. The bone marrow stem cells give rise to cells of all hematopoietic lineages, through the procedure of hematopoiesis. Lymphoid progenitor cells are created by this method and pass to the thymus wherein poor choice eliminates T cells located to be reactive to self. The lifestyles of donor stem cells in the recipient’s bone marrow causes donor reactive T cells to be taken into consideration self and go through apoptosis.