Several medications can be useful for those with CPVT. The mainstays of treatment are beta blockers, which block the consequences of adrenaline and other catecholamines at the heart, reducing the risk of strange coronary heart rhythms growing. Of all the beta blockers, nadolol has been established to be the handiest for treating CPVT. This drug lowers the coronary heart charge to a extra quantity than other beta blockers and most effective desires to be taken as soon as every day, decreasing the hazard of neglected doses. Nadolol may be tough to obtain and isn’t available in all international locations, and an opportunity beta blocker suitable for use in CPVT may be propranolol, which however has a extra complicated dosing regimen. Recently posted records recommend that the usage of selective beta blockers, such as atenolol, bisoprolol, or metoprolol, is associated with very excessive remedy failure quotes.
Flecainide is a category 1c antiarrhythmic drug that is recommended for those with CPVT who revel in atypical heart rhythms in spite of taking a beta blocker. Flecainide reduces the hazard of arrhythmias in those with CPVT, but it remains uncertain how Flecainide achieves this. Some have cautioned that Flecainide at once interacts with the cardiac ryanodine receptor, that is frequently odd in those with CPVT, whilst other propose that the anti-arrhythmic outcomes of Flecainide depend completely on its sodium channel blocking outcomes.
Verapamil is a calcium channel antagonist that, when blended with a beta blocker, may additionally lessen the risk of arrhythmias in patients with CPVT. Propafenone is some other antiarrhythmic that may lessen the risk of arrhythmias, probably thru direct results at the ryanodine receptor.