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Several nucleotide derivatives had been used as antivirals in opposition to hepatitis and HIV. Tenofovir disoproxil, Tenofovir alafenamide and Sofosbuvir are examples of NRTI used towards hepatitis. Whereas sure drugs like Mericitabine, Lamivudine, Entecavir and Telbivudine for example are nucleosides, but they may be metabolized into their bioactive nucleotide paperwork via phosphorylation.