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Brain-on-a-chip gadgets can cause shear stress on cells or tissue because of glide via small channels, which could result in cellular harm. These small channels additionally introduce susceptibility to the trapping of air bubbles which can disrupt glide and doubtlessly purpose harm to the cells. The good sized use of PDMS (polydimethylsiloxane) in brain-on-a-chip devices has some drawbacks. Although PDMS is reasonably-priced, malleable, and transparent, proteins and small molecules can be absorbed via it and later leech at out of control quotes.