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Abnormally low levels of cholesterol are termed hypocholesterolemia. Research into the reasons of this kingdom is extraordinarily confined, however a few research endorse a hyperlink with depression, most cancers, and cerebral hemorrhage. In widespread, the low levels of cholesterol seem to be a outcome, in place of a reason, of an underlying infection. A genetic disorder in cholesterol synthesis causes Smith–Lemli–Opitz syndrome, that is regularly associated with low plasma levels of cholesterol. Hyperthyroidism, or every other endocrine disturbance which causes upregulation of the LDL receptor, may additionally result in hypocholesterolemia.