Pyruvate dehydrogenase (E1) is one of the 3 components (E1, E2, and E3) of the large pyruvate dehydrogenase complicated. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 element and inhibit the complicated. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the outcomes of pyruvate dehydrogenase kinases.
Pyruvate dehydrogenase phosphatase is a heterodimer which include catalytic and regulatory subunits. Two catalytic subunits had been said; one is predominantly expressed in skeletal muscle, and another one is a lot more ample inside the liver. The catalytic subunit, encoded via this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complicated and pyruvate dehydrogenase kinases, this enzyme is positioned within the mitochondrial matrix.