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Although the time period has now and again been utilized in different approaches, in medical literature biotrauma is commonly defined as a intense inflammatory response produced within the lungs of sufferers who breathe by way of a mechanical ventilator for a protracted period of time. The time period turned into coined in a 1998 paper through L. N. Tremblay and A. S. Slutsky, titled Ventilator-brought about damage: from barotrauma to biotrauma. The message of that paper turned into that barotrauma because of stress differentials is simplest certainly one of several varieties of lung harm that a ventilator can produce.