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• Cognitive prostheses are implanted immediately in the brain, so biocompatibility is a very critical impediment to conquer. Materials used in the housing of the tool, the electrode fabric (such as iridium oxide), and electrode insulation should be selected for long term implantation. Subject to Standards: ISO 14708-3 2008-11-15, Implants for Surgery – Active implantable medical gadgets Part 3: Implantable neurostimulators.

• Crossing the blood–brain barrier can introduce pathogens or different materials that may cause an immune response. The mind has its personal immune gadget that acts differently from the immune system of the relaxation of the frame.